Research & Development World

Even on the largest supercomputers, simulations that explicitly resolve every blood cell can only cover a small volume. On Summit, Oak Ridge National Labs’ supercomputer, cell-resolved simulations topped out at roughly a three-millimeter cube. Exascale machines like Aurora and Frontier have pushed that to about a one-centimeter cube with several billion cells, up from around 500 million, said Amanda Randles of Duke…

By Bill Holt, DO, Vice President, Neuroscience Therapeutic Area, ICON For neurologic monoclonal antibodies (mAbs), the scientific hurdle is no longer the primary barrier to success. Increasingly, operational execution—not efficacy—determines whether these therapies reach patients at scale. From multiple sclerosis (MS) to neuromyelitis optica spectrum disorder (NMOSD) to early Alzheimer’s disease, mAbs have moved from…

Asisloglycoprotein receptors (ASGPRs) on healthy hepatocyte membranes physiologically function in clearing glycoproteins containing galactose or N-acetylglucosamine residues from the circulation. In mammalian circulation, approximately 90% of proteins are glycoproteins, typically adorned with terminal sialic acid residues. Physiologically, as these glycoproteins age, sialic acids are removed, exposing galactose, lactose, or N-acetylgalactosamine residues. These exposed sugars are…

Researchers have developed molecular quantum nanosensors (MoQNs) designed to operate in the cytoplasm and nuclei of living cancer cells to map radical-generation processes and thermal dynamics that are linked to cancer-associated cellular physiology.  The sensors use molecular-level uniformity to achieve a threefold enhancement in spectral resolution and superior thermometric specificity. The platform enables absolute temperature…

Idaho National Laboratory (INL) is collaborating with Argonne, Oak Ridge and Sandia National Laboratories, as well as four universities and more than 20 industry partners, on a three-year project to bring agentic AI to nuclear engineering. The principal investigator said the project, called Prometheus, will aim to compress the time to get a nuclear power…

Researchers led by Pacific Northwest National Laboratory have combined two X-ray techniques to watch how a molecule’s electrons and its surrounding water reorganize together during a reaction that underpins photosynthesis and cellular metabolism in what the team says is the first study to combine these techniques to capture that interplay in a single experiment. They published their work in Nature…

Solar arrays have been standard spacecraft hardware for decades, but their tendency to flex can complicate maneuvers needing precision such as docking. To tame the wobble, Southwest Research Institute (SwRI) developed PaSTA, a technology that can bring rigidity to deployable structures on spacecraft, thus enabling autonomous spacecraft docking operations. PaSTA also happens to be one…

Palo Alto–based startup Architect Labs, which emerged from stealth in June with a $24 million seed round, is boasting that its AI-designed and validated Redwood chip beats one NVIDIA edge product, the Jetson Orin Nano, in a specific AI-inference comparison. The company projects that a Samsung 8 nm implementation of Redwood would deliver 1.75× the…

    AI’s spending boom, which has continued mostly unabated so far in 2026, has left its imprint on many of this year’s world-leading innovators. In pharma, Eli Lilly has brought its LillyPod supercomputer online, and Roche has deployed NVIDIA-based AI computing infrastructure. Bristol Myers Squibb has announced plans to expand its existing infrastructure with…