Research & Development World

Even on the largest supercomputers, simulations that explicitly resolve every blood cell can only cover a small volume. On Summit, Oak Ridge National Labs’ supercomputer, cell-resolved simulations topped out at roughly a three-millimeter cube. Exascale machines like Aurora and Frontier have pushed that to about a one-centimeter cube with several billion cells, up from around 500 million, said Amanda Randles of Duke…

By Bill Holt, DO, Vice President, Neuroscience Therapeutic Area, ICON For neurologic monoclonal antibodies (mAbs), the scientific hurdle is no longer the primary barrier to success. Increasingly, operational execution—not efficacy—determines whether these therapies reach patients at scale. From multiple sclerosis (MS) to neuromyelitis optica spectrum disorder (NMOSD) to early Alzheimer’s disease, mAbs have moved from…

Hansa Biopharma, the Swedish company behind the immunoglobulin G (IgG)-cleaving enzyme imlifidase, will use the AI protein-engineering platform from Dutch-Swiss firm Cradle to design its next generation of autoimmune drug candidates, the companies announced Oct. 1. Hansa’s scientists will combine Cradle’s tools with Hansa’s existing experimental data, disease knowledge and protein-engineering expertise. “We’re not building…

Researchers have developed molecular quantum nanosensors (MoQNs) designed to operate in the cytoplasm and nuclei of living cancer cells to map radical-generation processes and thermal dynamics that are linked to cancer-associated cellular physiology.  The sensors use molecular-level uniformity to achieve a threefold enhancement in spectral resolution and superior thermometric specificity. The platform enables absolute temperature…

Idaho National Laboratory (INL) is collaborating with Argonne, Oak Ridge and Sandia National Laboratories, as well as four universities and more than 20 industry partners, on a three-year project to bring agentic AI to nuclear engineering. The principal investigator said the project, called Prometheus, will aim to compress the time to get a nuclear power…

Researchers led by Pacific Northwest National Laboratory have combined two X-ray techniques to watch how a molecule’s electrons and its surrounding water reorganize together during a reaction that underpins photosynthesis and cellular metabolism in what the team says is the first study to combine these techniques to capture that interplay in a single experiment. They published their work in Nature…

A team of researchers at the Dalian University of Technology in China designed and 3D-printed a spacecraft shield consisting of arrays of hollow, water-filled aluminum eggshells between two plates, reporting that it slowed projectiles by as much as 65% in simulations. Whether the design will hold up against real projectiles remains to be seen. The…

The ChatGPT-maker OpenAI will license Synopsys’ chip design software to develop GPT-Synopsys, a specialized AI model the companies plan to sell through a service bundling computing, model access and software licenses. The partnership centers on pairing OpenAI’s frontier AI models with Synopsys’ Electronic Design Automation (EDA) software. The multiyear agreement announced Sept. 30, alongside Synopsys’…

The International Space Station (ISS) National Laboratory launched its Orbital Edge Accelerator last year, funding six startups with its first cohort. This year, the lab split the program into two tracks, one focused on dual-use applications and one for in-space manufacturing and space biology. The ISS National Laboratory selected a total of eight early-stage startups…